Ben Pascoe

BP_200x333Milner Genomics Centre Manager
/Research Fellow

Department of Biology & Biotechnology
University of Bath, 4 South 0.39

Twitter: @benizao
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Qualifications
BSc (Hertfordshire, 2004)
DPhil (Sussex, 2008)
LFHCfS (2015)

Research Fellow in Pathogen Genomics   June 2016 – present

Pathogen genomics of sequenced bacterial pathogen collections comparing large amounts of isolate data to form evolutionary theories which can then be tested in our lab. My particular areas of interest include the evolution of transmission factors such as ability to form biofilm, oxygen tolerance and other stress responses which equip isolates for increased persistence and survival during transmission and infection (Pascoe et al. 2017; Yahara &  Méric et al. 2017; Dearlove et al. 2016; Pascoe et al. 2015).

Selected publications (In total 39 publications, H-Index: 14; citations: 698)
Campylobacter global epidemiology

  • Méric, G., McNally, A., Pesssia, A., Mourkas, E., Pascoe, B., [..]., Sheppard, SK. (2018) Convergent amino acid signatures in polyphyletic Campylobacter jejuni sub-populations suggest human niche tropism. Genome Biology & Evolution 10(3): 763-774
  • Pascoe, B.; Méric, G., Yahara K., […] Jolley, KA., Maiden, MCJ., McCarthy, N., Didelot, X., Parker, CT. & Sheppard, SK. (2017) Local genes for local bacteria: evidence of allopatry in the genomes of transatlantic Campylobacter populations Molecular Ecology 26 (17): 4497-4508 [PeerJ doi: 10.7287peerj.preprints.2638v2]
  • Thépault, A., Méric, G., Rivoal, K., Pascoe, B., Mageiros, L., Touzain, F., Rose, V., Béven, V., Chemaly, M., Sheppard, SK. (2017) Genome-wide identification of host-segregating epidemiological markers for source attribution in Campylobacter jejuni AEM 83 (7): e03085-16
  • Dearlove B, Cody A,Pascoe B, Méric G, Wilson D, Sheppard SK (2016) Rapid host switching in generalist Campylobacter strains erodes the signal for tracing human infections. The ISME Journal 10 (3): 721-9 [arXiv:1504.01607]

 Pathogen genomics in LMICs

  • Boonkhot, P., Pascoe, B. (joint), Williams, LK., […] Patchanee, P. & Sheppard, SK. (Accepted) Enhanced biofilm formation is associated with extended spectrum β-lactam producing Salmonella found in the Thai pork production process Frontiers in Microbiology
  • Rossi, GAM., […] Pascoe, B., […] Fukumasu, H., Sheppard, SK. & Vidal, AMC. (2018) Comparative genomic survey of Bacillus cereus sensu stricto isolates from the dairy production chain in Brazil FEMS Microbiology Letters 365(3)
  • Vale, FF., Nunes, A., Oleastro, M., Gomes, JP., Sampaio, D., Rocha, R., Vítor, J., Engstrand, L., Pascoe, B., Berthenet, E., Sheppard, SK., Hitchings, MD., Mégraud, F., Vadivelu, J., Lehours, P. (2017) Genomic structure and insertion sites of Helicobacter pylori prophages from various geographical origins Scientific Reports 7:42471; DOI: 1038/srep42471
  • Yan, X., Li, Z., Chlebowicz, MA., Tao, X., Ni, M., Hu, Y., Li, Z., Grundmann, H., Murray, S., Pascoe, B., Sheppard, SK., Bo, X., van Dijl, JM., Du, P., Zhang, M., You, Y., Yu, X., Meng, F., Wang, S., and Zhang, J. (2016) Livestock-associated Staphylococcus aureus ST9 isolates from Chinese pigs carry the lsa(E) gene and are quinupristin/ dalfopristin resistant IJMM doi:10.1016/j.ijmm.2016.08.001

 Genome-wide association of transmission and infection traits

  • Berthenet, E., Yahara, K., Thorell, K., Engstrand, L., Enroth, H., Pascoe, B., Méric, G., Burette, A., Megraud, F., Atherton, J., Smith, S., Wilkinson, TS., Hitchings, MD., Mikhail, JM., Falush, D. & Sheppard, SK. (Under review) Predicting gastric cancer risk: small Helicobacter pylori genome-wide association study shows promise. BMC Biology 16:84
  • Murray, S.; Pascoe, B. (joint); Méric, G., Mageiros, L., Yahara, K., Hitchings, MD., Friedmann, Y., Gormley, FJ; Wendlandt, S; Schwarz, S.; Lamble S, Bray JE, Bowden, R.; Jolley KA, Maiden, MCJ., Corander, J.; Fitzgerald, JR.; Sheppard, SK. (2017) Recombination-mediated host-adaptation by avian Staphylococcus aureus. Genome Biology & Evolution 9 (4): 830-842; DOI: 10.1093/gbe/evx037
  • Yahara, K., Méric, G., Taylor, AJ., de Vries, SPW., Murray, S., Pascoe, B., Mageiros, L., Torralbo, A., Vidal, A., Ridley, A., Komukai, S., Wimalarathna, H., Cody, AJ., Colles, FM., McCarthy, N., Harris, D., Bray, JE., Jolley, KA., Maiden, MCJ., Bentley, SD., Parkhill, J., Bayliss, CD., Grant, A., Maskell, D., Didelot, X., Kelly, DJ., Sheppard, SK. (2016) Genome-wide association of functional traits linked with Campylobacter jejuni survival from farm to fork. Environmental Microbiology 19(1):361-380 doi:10.1111/1462-2920.13628 [PeerJ preprint: doi.org/10.7287]
  • Pascoe B, Méric G, Murray S, Yahara K, Magerios L, Bowen R, Jones NH, Jeeves RE, Lappin-Scott HM, Asakura H, Sheppard SK (2015) Enhanced biofilm formation and multi-host transmission evolve from divergent genetic backgrounds in Campylobacter jejuni. Environmental Microbiology 17:(11) 4779–4789
  • McNally, A., Oren, Y., Kelly, D., Pascoe, B., Dunn, S., Sreecharan, T., Vehkala, M., Välimäki, N., Prentice, M., Ashour, A.; Avram, O., Pupko, T., Dobrindt, U., Literak, I., Guenther, S., Schaufer, K., Wieler, L., Zhiyoung, Z., Sheppard, S.; McInerney, J., Corander, J. (2016) Combined analysis of variation in core, accessory and regulatory genome regions provides a super-resolution view into the evolution of bacterial populations. Plos Genetics 12 (9): e1006280 **Top 50 most downloaded PLoS Genetics papers 2016**
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