Guillaume Méric

P 12 Dr Guillaume Meric - Copy2Research Fellow

The Milner Centre for Evolution
Department of Biology & Biotechnology
University of Bath, 4 South, Lab 0.39
Claverton Down
Bath, BA2 7AY
United Kingdom

Twitter: @phylogeo
Google Scholar | ResearchGate | ORCID

E-mail: g.meric@bath.ac.uk
Phone: +44 (0) 1225-385046

Research interests

My interests are broad and revolve around the ecology and evolution of infectious disease, how populations of pathogenic organisms interact with their human and animal (bird) hosts and the natural environment. I am interested in how the ecology and environment can impact on pathogen evolution, how pathogens emerge from background asymptomatic carried populations, and how they jump and transmit between various hosts. In practice and using both “dry” bioinformatic and “wet” lab experimental approaches, I contribute to the sampling and subsequent analysis of hundreds/thousands of bacterial isolates from various species at the genomic and phenotypic levels. A general goal is to identify candidate adaptive and functional differences, in silico and in vitro/vivo. Recently, I contributed to develop an application of pangenome-wide association studies (pGWAS) to bacterial genomics, which we have used/are using to study Campylobacter, Staphylococcus and Escherichia coli populations.

Curriculum

2016-present: Research Fellow, The Milner Centre for Evolution (University of Bath)
2016-present: Honorary Clinical Scientist, Public Health Wales NHS Trust (Singleton Hospital, Swansea)

2014-2016: NISCHR Research Fellow (Swansea University Medical School)
2012-2014: Research Assistant (Swansea University Medical School)
2007-2012: PhD (IFR/UEA, Norwich) in Microbiology
2005-2007: MSc (UCBL/INSA, Lyon, France) in Microbial Ecology and Evolution
2002-2005: BSc (UCBL, Lyon, France + U. Sherbrooke, QC, Canada) in General Biology

Edited book

  1. Sheppard SK, Méric G.(eds.) Campylobacter Ecology and Evolution, Caister Academic Press, April 2014, c.350 pages [Publisher][PDF information] ISBN: 978-1-908230-36-2

Selected publications (* denotes shared first authorship)

  1. Méric G, Hitchings MD, Pascoe B, Sheppard SK. (2016) From Escherich to the Escherichia coli genome. The Lancet Infectious Diseases 16(6):634–636 . [Publisher]
  2. Yahara K*, Méric G*, Taylor AJ, de Vries SP, Murray S, Pascoe B, Mageiros L, Torralbo A, Vidal A, Ridley AM, Komukai S, Wimalarathna H, Cody AJ, Colles FM, McCarthy ND, Harris D, Bray JE, Jolley KA, Maiden MC, Bentley SD, Parkhill J, Bayliss CD, Grant AJ, Maskell D, Didelot X, Kelly DJ, Sheppard SK. (2016) Genome-wide association of functional traits linked with Campylobacter jejuni survival from farm to fork. Environmental Microbiology 19(1):361–380. [Publisher].
  3. Méric G, Miragaia M, de Been M, Yahara K, Pascoe B, Mageiros L, Mikhail J, Harris LG, Wilkinson TS, Rolo J, Lamble S, Bray JE, Jolley KA, Hanage WP, Bowden R, Maiden MCJ, Mack D, de Lencastre H, Feil EJ, Corander J, Sheppard SK (2015) Ecological overlap and horizontal gene transfer in Staphylococcus aureus and Staphylococcus epidermidis.Genome Biology and Evolution. 7 (5): 1313-1328. [Publisher]
  4. Sheppard SK, Didelot X, Meric G, Torralbo A, Jolley KA, Kelly DJ, Bentley SD, Maiden MCJ, Parkhill J, Falush D. Genome-wide association study identifies vitamin B5 biosynthesis as a host specificity factor in Campylobacter. Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11923-7. [Pubmed][Journal]
  5. Meric G, Kemsley EK, Falush D, Saggers EJ, Lucchini S (2013) Phylogenetic distribution of traits associated with plant colonization in Escherichia coli. Environ mental Microbiology 2013 Feb;15(2):487-501. [Pubmed][Journal]

Full publication list

  1. Pascoe B, Meric G, Yahara K, Wimaralathna H, Murray S, Hitchings MD, Sproston EL, Carrillo CD, Taboada EN, Cooper KK, Huynh S, Cody AJ, Jolley KA, Maiden MC, McCarthy ND, Didelot X, Parker C, Sheppard SK. (2016) Local genes for local bacteria: evidence of allopatry in the genomes of transatlantic Campylobacter populations. Molecular Ecology (in press) [Publisher].
  2. Murray S*, Pascoe B*, Méric G, Mageiros L, Yahara K, Hitchings MD, Friedmann Y, Gormley FJ, Mack D, Bray JE, Lamble S, Bowden R, Jolley KA, Maiden MCJ, Wendlandt S, Schwarz S, Corander J, Fitzgerald JR, Sheppard SK. (2016) Recombination-mediated host-adaptation by avian Staphylococcus aureus. Genome Biology and Evolution (in press).
  3. Esson D, Gupta S, Bailey D, Wigley P, Wedley A, Matherd AE, Méric G, Mastroeni P, Sheppard SK, Thomson NR, Parkhill J, Maskell D, Christie G, Grant AJ. (2017) Identification and initial characterisation of a protein involved in Campylobacter jejuni cell shape. Microbial Pathogenesis 104:202–211 [Publisher]
  4. Thepault A, Méric G, Rivoal K, Pascoe B, Mageiros L, Touzain F, Rose V, Beven V, Chemaly M, Sheppard SK. (2017) Genome-wide identification of host-segregating epidemiological markers for source attribution in Campylobacter jejuni. Applied and Environmental Microbiology. (in press)
  5. Esson D, Mather AE, Scanlan E, Gupta S, de Vries SPW, Bailey D, Harris SR, McKinley TJ, Méric G, Berry SK, Mastroeni P, Sheppard SK, Christie G, Thomson NR, Parkhill J, Maskell D, Grant AJ. (2016) Genomic variations leading to alterations in cell morphology of Campylobacter spp. Scientific Reports. (in press) [Publisher].
  6. Woodcock DJ, Krusche P, Strachan NJC, Forbes KJ, Cohan FM, Méric G, Sheppard SK. (2016) Genomic plasticity and rapid host switching promote the evolution of generalism in the zoonotic pathogen Campylobacter. bioRxiv 080077; doi:10.1101/080077 [Pre-print].
  7. Monteil CL, Yahara K, Studholme DJ, Mageiros L, Méric G, Swingle B, Morris CE, Vinatzer BA, Sheppard SK. (2016) Population-genomic insights into emergence, crop-adaptation, and dissemination of Pseudomonas syringae pathogens. Microbial Genomics (in press) [Publisher].
  8. Sankar A, Malone B, Bayliss SC, Pascoe B, Méric G, Hitchings MD, Sheppard SK, Feil EJ, Corander J, Honkela A. (2016) Bayesian identification of bacterial strains from sequencing data. Microbial Genomics 2(8) [Publisher]
  9. Gilbert MJ, Miller WG, Yee E, Zomer AL, van der Graaf-van Bloois L, Fitzgerald C, Forbes KJ, Méric G, Sheppard SK, Wagenaar JA, Duim B. (2016) Comparative Genomics of Campylobacter fetus from Reptiles and Mammals Reveals Divergent Evolution in Host-Associated Lineages. Genome Biology and Evolution. 2;8(6):2006-19. [Pubmed]
  10. Méric G, Hitchings MD, Pascoe B, Sheppard SK. (2016) From Escherich to the Escherichia coli genome. The Lancet Infectious Diseases 16(6):634–636 . [Publisher]
  11. Numminen E, Gutmann MU, Shubin M, Marttinen P, Méric G, van Schaik W, Coque T, Baquero F, Willems R, Sheppard SK, Feil EJ, Hanage WP, Corander J. (2016) The impact of host metapopulation structure on the population genetics of colonizing bacteria. Journal of Theoretical Biology (in press)
  12. Harris LG, Murray S, Pascoe B, Bray J, Meric G, Mageiros L, Wilkinson TS, Jeeves R, Rohde H, Schwarz S, de Lencastre H, Miragaia M, Rolo J, Bowden R, Jolley KA, Maiden MC, Mack D, Sheppard SK. (2016) Biofilm Morphotypes and Population Structure among Staphylococcus epidermidis from Commensal and Clinical Samples. PLoS One 11(3):e0151240. [Pubmed]
  13. Pascoe B, Méric G, Murray S, Mageiros L, Yahara K, Bowen R, Jones NH, Jeeves RE, Lappin-Scott HM, Asakura H, Sheppard SK. (2015) Enhanced biofilm formation evolves from divergent genetic backgrounds in host generalist Campylobacter jejuni. Environmental Microbiology (in press).
  14. Dearlove B, Cody A, Pascoe B, Méric G, Wilson D, Sheppard SK. (2015) Rapid host switching in generalist Campylobacter strains erodes the signal for tracing human infections. The ISME Journal [Pubmed].
  15. Facey P, Meric G, Hitchings MD, Pachebat JA, Hegarty MJ, Chen X, Morgan LVA, Hoeppner JE, Whitten MMA, Kirk WDJ, Dyson PJ, Sheppard SK, Del Sol R. (2015) Draft genomes, phylogenetic reconstruction and comparative genomics of two novel cohabiting bacterial symbionts isolated from Frankliniella occidentalisGenome Biology and Evolution doi: 10.1093/gbe/evv136 (in press) [Publisher]
  16. Méric G, Miragaia M, de Been M, Yahara K, Pascoe B, Mageiros L, Mikhail J, Harris LG, Wilkinson TS, Rolo J, Lamble S, Bray JE, Jolley KA, Hanage WP, Bowden R, Maiden MCJ, Mack D, de Lencastre H, Feil EJ, Corander J, Sheppard SK (2015) Ecological overlap and horizontal gene transfer in Staphylococcus aureus and Staphylococcus epidermidis.Genome Biology and Evolution. (in press)
  17. Morley L, McNally A, Paszkiewicz K, Corander J, Méric G, Sheppard SK, Blom J, Manning G. Gene loss and lineage specific restriction-modification systems associated with niche differentiation in the Campylobacter jejuni Sequence Type 403 clonal complex. Applied and Environmental Microbiology. 2015 (in press).
  18. Torralbo A, Borge C, Garcia-Bocanegra I, Méric G, Perea A, Carbonero A (2015) Higher resistance of Campylobacter coli compared to Campylobacter jejuni at chicken slaughterhouse. Comparative Immunology, Microbiology and Infectious Diseases, 2015 (in press) [Publisher]
  19. Searle LJ*, Méric G*, Porcelli I, Sheppard SK, Lucchini S. Variation in siderophore biosynthetic gene distribution and production across environmental and faecal populations of Escherichia coli. Plos One 2015. Mar 10;10(3):e0117906 [Publisher] [Pubmed].
  20. Baily JL, Méric G, Bayliss S, Foster G, Moss SE, Watson E, Pascoe B, Mikhail J, Pizzi R, Goldstone RJ, Smith DG, Willoughby K, Hall AJ, Sheppard SK*, Dagleish MP*. Evidence of land-sea transfer of the zoonotic pathogen Campylobacter to a wildlife marine sentinel species. Molecular Ecology 2015 [Pubmed]
  21. Sheppard SK, Cheng L, Méric G, de Haan CPA, Llarena A-K, Marttinen P, Vidal A, Ridley A, Clifton-Hadley F, Connor TR, Strachan NJC, Forbes K, Colles FM, Jolley KA, Bentley SD, Maiden MCJ, Hänninen M-L, Parkhill J, Hanage WP, Corander J Cryptic ecology among host generalist Campylobacter jejuni in domestic animals. Mol Ecol. 2014 (in press) [Publisher]
  22. Meric G, Yahara K, Mageiros L, Pascoe B, Maiden MCJ, Jolley KA, Sheppard SK. A reference pan-genome approach to comparative bacterial genomics: identification of novel epidemiological markers in pathogenic Campylobacter. Plos One. 2014 [Publisher]
  23. Sheppard SK, Didelot X, Meric G, Torralbo A, Jolley KA, Kelly DJ, Bentley SD, Maiden MCJ, Parkhill J, Falush D. Genome-wide association study identifies vitamin B5 biosynthesis as a host specificity factor in Campylobacter. Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11923-7. [Pubmed][Journal]
  24. Sheppard SK, Didelot X, Jolley KA, Darling AE, Pascoe B, Meric G, Kelly DJ, Cody A, Colles FM, Strachan NJ, Ogden ID, Forbes K, French NP, Carter P, Miller WG, McCarthy ND, Owen R, Litrup E, Egholm M, Affourtit JP, Bentley SD, Parkhill J, Maiden MC, Falush D. (2013) Progressive genome-wide introgression in agricultural Campylobacter coli.Mol Ecol. 2013 Feb;22(4):1051-64. [Pubmed][Journal]
  25. Meric G, Kemsley EK, Falush D, Saggers EJ, Lucchini S (2013) Phylogenetic distribution of traits associated with plant colonization in Escherichia coli. Environ Microbiol. 2013 Feb;15(2):487-501. [Pubmed][Journal]
  26. Didelot X, Meric G, Falush D, Darling AE (2012) Impact of homologous and non-homologous recombination in the genomic evolution of Escherichia coli. BMC Genomics. 2012 Jun 19;13:256. [Pubmed][Journal]
  27. Huang Z, Meric G, Liu Z, Ma R, Tang Z, Lejeune P (2009) luxS-based quorum-sensing signaling affects Biofilm formation in Streptococcus mutans. J Mol Microbiol Biotechnol. 2009;17(1):12-9. [Pubmed][Journal]