The Milner Centre for Evolution
Department of Biology & Biotechnology
University of Bath, 4 South, Lab 0.39
Bath, BA2 7AY
Phone: +44 (0) 1225-385046
My research interests are broad and revolve around the ecology and evolution of environmental and pathogenic bacteria in relation to their animal or human hosts. I study different levels of these host-pathogen/host-bacterial interactions, mainly with a microbial population biology angle: how the ecology and environment can impact on bacterial and microbial population evolution, how pathogens emerge from background asymptomatic carried populations, and how microbes jump and transmit between various hosts. For example, I try to understand the impact of host factors (ecology, physiology or immunity) on the evolution and adaptation of the bacterial species they carry. Recently, I have been interested in how intensive agriculture and the domestication of livestock could have an impact on the microbes/pathogens they carry, on their evolution, ecology and virulence to humans and animals.
My work relies on a combination of field sampling, in vitro and in vivo laboratory work, genome sequencing and bioinformatic analyses. In the past few years, I have focused on the population genomics and ecology of bacteria, including the zoonotic pathogen Campylobacter and Escherichia coli populations, but also nosocomial pathogens from Staphylococcus, and insect-associated Bacillus thuringiensis.
2016-present: Research Fellow, The Milner Centre for Evolution (University of Bath)
2016-2017: Honorary Clinical Scientist, Public Health Wales NHS Trust (Singleton Hospital, Swansea)
2014-2016: NISCHR Research Fellow (Swansea University Medical School)
2012-2014: Research Assistant (Swansea University Medical School)
2007-2012: PhD (IFR/UEA, Norwich) in Microbiology
2005-2007: MSc (UCBL/INSA, Lyon, France) in Microbial Ecology and Evolution
2002-2005: BSc (UCBL, Lyon, France + U. Sherbrooke, QC, Canada) in General Biology
- Sheppard SK, Méric G.(eds.) Campylobacter Ecology and Evolution, Caister Academic Press, April 2014, c.350 pages [Publisher][PDF information] ISBN: 978-1-908230-36-2
Selected publications (* denotes shared first authorship)
- Méric G, Hitchings MD, Pascoe B, Sheppard SK. (2016) From Escherich to the Escherichia coli genome. The Lancet Infectious Diseases 16(6):634–636 . [Publisher]
- Yahara K*, Méric G*, Taylor AJ, de Vries SP, Murray S, Pascoe B, Mageiros L, Torralbo A, Vidal A, Ridley AM, Komukai S, Wimalarathna H, Cody AJ, Colles FM, McCarthy ND, Harris D, Bray JE, Jolley KA, Maiden MC, Bentley SD, Parkhill J, Bayliss CD, Grant AJ, Maskell D, Didelot X, Kelly DJ, Sheppard SK. (2016) Genome-wide association of functional traits linked with Campylobacter jejuni survival from farm to fork. Environmental Microbiology 19(1):361–380. [Publisher].
- Méric G, Miragaia M, de Been M, Yahara K, Pascoe B, Mageiros L, Mikhail J, Harris LG, Wilkinson TS, Rolo J, Lamble S, Bray JE, Jolley KA, Hanage WP, Bowden R, Maiden MCJ, Mack D, de Lencastre H, Feil EJ, Corander J, Sheppard SK (2015) Ecological overlap and horizontal gene transfer in Staphylococcus aureus and Staphylococcus epidermidis.Genome Biology and Evolution. 7 (5): 1313-1328. [Publisher]
- Sheppard SK, Didelot X, Meric G, Torralbo A, Jolley KA, Kelly DJ, Bentley SD, Maiden MCJ, Parkhill J, Falush D. Genome-wide association study identifies vitamin B5 biosynthesis as a host specificity factor in Campylobacter. Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11923-7. [Pubmed][Journal]
- Meric G, Kemsley EK, Falush D, Saggers EJ, Lucchini S (2013) Phylogenetic distribution of traits associated with plant colonization in Escherichia coli. Environ mental Microbiology 2013 Feb;15(2):487-501. [Pubmed][Journal]